NEWS

Time-efficient fabrication method for 3D-printed microfluidic devices

Abstract Recent developments in 3D-printing technology have provided a time-efficient and inexpensive alternative to the fabrication of microfluidic devices. At present, 3D-printed microfluidic systems face the challenges of post-processing, non-transparency, and being time consuming, limiting their practical application. In this study, a time-efficient and inexpensive fabrication method was developed for 3D-printed microfluidic devices. The material [...]

Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture

1 Introduction To understand interactions between living matter and artificial materials, tissue engineering research groups focus on the development of 3D scaffolds with increasingly controllable properties, reaching from biochemical interactions at molecular scale to nanoscale hydrogel networks, micrometer-scale pores, and macroscopic architectures.[1] Soft hydrogel scaffolds are conventionally formed by crosslinking a precursor solution, resulting in soft, [...]

Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

Abstract Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific functional networks underlying biological processes. Here, we present a streamlined workflow combining microfluidic chips for all-in-one proteomic sample preparation and data-independent acquisition (DIA) mass spectrometry (MS) for proteomic analysis down to the single-cell level. The proteomics chips enable multiplexed and automated cell isolation/counting/imaging and sample [...]

Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor

Abstract Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target [...]

Continuous artificial synthesis of glucose precursor using enzyme-immobilized microfluidic reactors

Introduction The world is moving rapidly into food crisis due to extreme weather, shortage of farmland, and population explosion. And glucose is the basic material of food produced by green plants using the natural photosynthesis (NPS)1. However, the NPS suffers from low-energy efficiency (~1%) and is greatly limited by soil, climate, water, and labor2,3. It [...]

Development of a sticker sealed microfluidic device for in situ analytical measurements using synchrotron radiation

Microfluidic devices operate with small amounts of samples through micrometer and/or sub-micrometer channels1. As the main characteristics, these devices show reduced size, low weight, and high throughput.

Paper microfluidic implementation of loop mediated isothermal amplification for early diagnosis of hepatitis C virus

The early diagnosis of active hepatitis C virus (HCV) infection remains a significant barrier to the treatment of the disease and to preventing the associated significant morbidity and mortality seen, worldwide.

Microfluidic technology for circadian studies

We designed and developed a microfluidic platform (Supplementary Fig. S7) to perform frequency-encoded metabolic perturbations, while recording circadian gene expression by luminescence detectors.